Computationally straighted C. elegans meiotic chromosome from the late pachytene region of the germ line; stained by HTP-3 and COSA-1
Oocyte nucleus from the C. elegans germline stained with COSA-1 to mark meiotic crossover formation
Oocyte nucleus from the C. elegans germline stained with COSA-1 to mark meiotic crossover formation

Cori K. Cahoon and Diana E. Libuda (2019).  Leagues of their own: sexually dimorphic features of meiotic prophase I.  Chromosoma  doi:10.1007/s00412-019-00692-x


Mara Schvarzstein, Divya Pattabiraman, Diana E. Libuda, Ajit Ramadugu, Angela Tam, Enrique Martinez-Perez, Baptiste Roelens, Karl Zawadzki, Rayka Yokoo, Simona Rosu, Kentaro Nabeshima, and Anne M. Villeneuve (2014).  DNA helicase HIM-6/BLM promotes MutSĪ³-dependent crossovers and antagonizes MutSĪ³-independent interhomolog associations during C. elegans meiosis.

Genetics, 198(1):193-207, doi:10.1534/genetics.114.161513


Diana E. Libuda, Satoru Uzawa, Barbara J. Meyer, and Anne M. Villeneuve (2013).  Meiotic chromosome structures constrain and respond to designation of crossover sites.

Nature  502, 703-706.

                      -recommended in Faculty of 1000


Simona Rosu, Karl A. Zawadzki, Ericca L. Stamper, Diana E. Libuda, Angela L. Reese, Abby F. Dernburg, and Anne M. Villeneuve (2013).  The C. elegans DSB-2 protein reveals a regulatory network that controls competence for meiotic DSB formation.

PLoS Genetics 9(8): e1003674.


Simona Rosu, Diana E. Libuda, and Anne M. Villeneuve (2011).  Robust crossover assurance and regulated interhomolog access maintain meiotic crossover number.

Science 334, 1286-9.

                      -recommended in Faculty of 1000


Diana E. Libuda and Fred Winston (2010).  Alterations in DNA replication and histone levels promote histone gene amplification in Saccharomyces cerevisiae.

Genetics, 184, 985-97.


Diana E. Libuda and Fred Winston (2006).  Amplification of histone genes by circular chromosome formation in Saccharomyces cerevisiae.

Nature, 443, 1003-7.

                      -recommended in Faculty of 1000


Sanja Ivkovic, Byeong S. Yoon, Steven N. Popoff, Fayez F. Safadi, Diana E. Libuda, Robert C. Stephenson, Aaron Daluiski, and Karen M. Lyons (2003).  Connective Tissue Growth Factor is an essential regulator of skeletal development.

Development, 130, 2779-91.


Libuda Lab home page button; DSBs marked by RAD-51 foci in a single C. elegans germ cell nucleus